Biotic Elicitor-Induced Enhancement of Bioactive Metabolite Production and Antioxidant Activity in Vitro Cultured Medicinal Plants
DOI:
https://doi.org/10.59890/ijnhs.v4i4.2Keywords:
Antioxidant Activity, Biotic Elisitors, Culture in Vitro, Bioactive Metabolites, Medicinal PlantsAbstract
Medicinal plants are a source of bioactive metabolites, but in vitro culture productivity is often low. This study aims to analyze the influence of the type, concentration, and duration of biotic elisters on the accumulation of metabolites and antioxidant activity. Systematic literature review followed PRISMA 2020 via Scopus, Web of Science, PubMed, and ScienceDirect; 42 articles for the period 2021–2025 were analyzed descriptive-thematically. A total of 34 studies (81.0%) reported an increase in at least one metabolite, while 24 of 30 studies (80.0%) showed an increase in antioxidant activity. Fungal elicitors most often increase metabolites, while chitosan shows the highest proportion of antioxidant increases. The optimal response generally occurs at intermediate concentrations and 48 hours–7 days of exposure. Biotic elitheration has the potential to optimize phytochemical production, but it requires plant-specific, culture, dose, and time-specific standardization
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